Cyclic di-GMP Allosterically Inhibits the CRP-Like Protein (Clp) of Xanthomonas axonopodis pv. citri
- 15 November 2009
- journal article
- research article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 191 (22) , 7121-7122
- https://doi.org/10.1128/jb.00845-09
Abstract
The protein Clp from Xanthomonas axonopodis pv. citri regulates pathogenesis and is a member of the CRP (cyclic AMP receptor protein) superfamily. We show that unlike the DNA-binding activity of other members of this family, the DNA-binding activity of Clp is allosterically inhibited by its effector and that cyclic di-GMP serves as that effector at physiological concentrations.Keywords
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