Apolipoprotein E and atherosclerosis
- 1 June 2000
- journal article
- review article
- Published by Wolters Kluwer Health in Current Opinion in Lipidology
- Vol. 11 (3) , 243-251
- https://doi.org/10.1097/00041433-200006000-00004
Abstract
Apolipoprotein E plays a key protective role in atherosclerosis. Its capacity to safeguard against this disease can be attributed to at least three distinct functions. First, plasma apolipoprotein E maintains overall plasma cholesterol homeostasis by facilitating efficient hepatic uptake of lipoprotein remnants. Second, lesion apolipoprotein E in concert with apolipoprotein A-I facilitates cellular cholesterol efflux from macrophage foam cells within the intima of the lesion. Third, lesion apolipoprotein E directly modifies both macrophage- and T lymphocyte-mediated immune responses that contribute to this chronic inflammatory disease.Keywords
This publication has 69 references indexed in Scilit:
- Rapid Regression of Atherosclerosis Induced by Liver-Directed Gene Transfer of ApoE in ApoE-Deficient MiceArteriosclerosis, Thrombosis, and Vascular Biology, 1999
- Apo E structure determines VLDL clearance and atherosclerosis risk in miceJournal of Clinical Investigation, 1999
- ApoA1 Reduces Free Cholesterol Accumulation in Atherosclerotic Lesions of ApoE–Deficient Mice Transplanted With ApoE–Expressing MacrophagesArteriosclerosis, Thrombosis, and Vascular Biology, 1999
- An apolipoprotein E synthetic peptide targets to lipoproteins in plasma and mediates both cellular lipoprotein interactions in vitro and acute clearance of cholesterol-rich lipoproteins in vivo.Journal of Clinical Investigation, 1998
- Bone Marrow Transplantation in Apolipoprotein E–Deficient MiceArteriosclerosis, Thrombosis, and Vascular Biology, 1997
- Apolipoprotein E2 Transgenic RabbitsJournal of Biological Chemistry, 1997
- Macrophage-specific expression of human apolipoprotein E reduces atherosclerosis in hypercholesterolemic apolipoprotein E-null mice.Journal of Clinical Investigation, 1995
- Spontaneous Hypercholesterolemia and Arterial Lesions in Mice Lacking Apolipoprotein EScience, 1992
- Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cellsPublished by Elsevier ,1992
- Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells.Proceedings of the National Academy of Sciences, 1992