Teratogenic Effects of Hyperbaric Oxygen.

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Abstract
Summary Pregnant golden hamsters in early stages of gestation were exposed to hyperbaric oxygen at 3.0, 3.6, and 4.0 atmospheres for periods of 3 and 2 hours. One-fourth of the mothers developed central nervous system signs during treatment and were sacrificed. A small but significant number of fetuses recovered late in gestation had severe gross congenital malformations, consisting of umbilical hernias, exencephaly, spina bifida, and limb defects. I wish to thank Dr. George Margolis, Dept. of Pathology, Dartmouth Medical School, for use of equipment and personnel supported by U.S.P.H.S. grant.