RESTRICTION SPECIFICITY OF VIRUS-SPECIFIC CYTO-TOXIC T-CELLS FROM THYMECTOMIZED IRRADIATED BONE-MARROW CHIMERAS RECONSTITUTED WITH THYMUS GRAFTS

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  • 1 January 1981
    • journal article
    • research article
    • Vol. 2  (6) , 321-327
Abstract
Adult-thymectomized lethally irradiated mice A that were reconstituted with T-cell-depleted bone marrow cells of (A .times. B)F1 origin plus fetal thymus grafts of (B .times. C)F1 origin generated virus-specific T cells restricted to B alone; adult-thymectomized and lethally irradiated (A .times. B)F1 mice that were reconstituted with T-cell-depleted bone marrow cells of (A .times. B)F1 origin plus fetal thymus grafts of A and of B origin generated virus-specific T cells restricted to A or to B. Obvious suppressive influences of host or stem-cell origin that might have explained results obtained with various irradiated bone marrow or thymus chimeras were not seen. The thymus'' influence on maturing T cells probably is one of the limiting steps in the selection of T cells'' restriction specificities.