Dynamic clinical studies with radioisotopes and the scintillation camera. II. Rose bengal I-131 liver function studies

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Abstract
The scintillation camera has been employed for dynamic liver function studies with rose bengal I131. This approach permits constant visual monitoring of hepatic uptake of labeled dye from the circulation and its excretion into the bilary tree and intestine. The rates of decline in blood radioactivity and Of hepatic isotope uptake have been characterized in normal subjects and distinguished from those obtained in patients with parenchymal dysfunction. This technique provides a unique timed anatomic record of the rate and magnitude of excretion of labeled dye, and initial studies indicate it to be of significant value in the differentiation of jaundice which can be Surgically corrected and that which can not. Technical limitations inherent in earlier procedures are no longer a problem. The study of liver function with the scintillation camera and rose bengal I131 represents an advance over previous methodology and this technique merits continued Investigation.