Effects of dietary xenobiotics on the metabolism of copper, .ALPHA.-tocopherol and cholesterol in rats.

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Abstract
The effects of dietary addition of some xenobiotics on tissue levels of copper and .alpha.-tocopherol in rats were studied with special reference to serum cholesterol. The chemicals added here were 0.05% polychlorinated biphenyls (PCB), 0.3% caffeine, 0.05%, 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT), 0.3% flavone, 0.3% chloretone, 0.3% 2-tert-butyl-4-methoxyphenol (BHA), 0.15% sodium phenobarbital, 0.15% phenytoin, 0.2% sodium pentobarbital, and 0.15% phenylbutazone. Of these chemicals, dietary PCB, caffeine DDT, flavone, chloretone, BHA and phenytoin raised the level of copper in liver, kidney, or serum. Serum .alpha.-tocopherol and cholesterol also increased with the additive or synergistic effects on these metabolisms. Moreover, these combined addition dietary 0.02% PCB with 0.2% BHA seemed to cause additive or synergistic effects on these metabolism. Moreover, these chemicals raised serum ceruloplasmin activity. In general, serum copper, ceruloplasmin activity and .alpha.-tocopherol were correlated with serum cholesterol in these dietary manipulations.