Intermittent fasting and dietary supplementation with 2‐deoxy‐D‐glucose improve functional and metabolic cardiovascular risk factors in rats

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Abstract
SPECIFIC AIMSExperiments were designed to test the hypothesis that intermittent fasting (IF) can improve cardiovascular risk factors in adult rats and that such effects can be mimicked by dietary supplementation with 2-deoxy-d-glucose (2DG), an analog of glucose that inhibits glycolysis. The studies were based on the concept that intermittent fasting is a metabolic stress that can improve cardiovascular function and enhance glucose metabolism.PRINCIPAL FINDINGS1. Rats maintained on an intermittent fasting feeding regimen exhibit reduced body weight and decreased body temperature, blood pressure (BP), and heart rate (HR) compared with rats fed ad libitum (Fig. 1⤻ ) Figure 1.IF and dietary supplementation with 2DG decrease BP and HR in rats. Values are the mean and se of determinations made in 5–8 rats. IF significantly reduced HR (P<0.01), mean BP (P<0.01), general activity (P<0.05), and body temperature (P<0.01). 2DG supplementation significantly reduced HR (P<0.05), mean BP (P<0.01), but had no significa...