Kinetic Evidence for the Existence and Mechanism of Formation of a Barrel Stave Structure from Pore-Forming Dendrimers
- 28 October 2003
- journal article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 125 (46) , 13984-13987
- https://doi.org/10.1021/ja036390h
Abstract
A dendritic approach to the construction of a homologous series of pore-forming amphiphiles has been developed, based on the use of spermidine, spermine, lysine, and cholic acid. A kinetic analysis of Na+ transport across bilayers of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine by three dendritic amphiphiles has provided the strongest evidence to date for a barrel stave structure.Keywords
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