Selective Transport of ATP across a Phospholipid Bilayer by a Molecular Umbrella
- 25 March 2003
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 125 (15) , 4436-4437
- https://doi.org/10.1021/ja0291336
Abstract
Acylation of each primary group of spermidine with cholic acid, followed by acylation of the secondary amino group using an activated form of Nα,Nδ,Nω-tri-CBZ-l-arginine, and subsequent hydrogenolysis, afforded a conjugate (i.e., 1) which readily transports adenosine 5-triphosphate, but not glutathione, across phospholipid bilayers made from 1-palmitoyl-2-oleyol-sn-glycero-3-phosphocholine and 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphatidylglycerol.Keywords
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