Nanoprobes with near-infrared persistent luminescence for in vivo imaging
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- 29 May 2007
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 104 (22) , 9266-9271
- https://doi.org/10.1073/pnas.0702427104
Abstract
Fluorescence is increasingly used for in vivo imaging and has provided remarkable results. Yet this technique presents several limitations, especially due to tissue autofluorescence under external illumination and weak tissue penetration of low wavelength excitation light. We have developed an alternative optical imaging technique by using persistent luminescent nanoparticles suitable for small animal imaging. These nanoparticles can be excited before injection, and their in vivo distribution can be followed in real-time for more than 1 h without the need for any external illumination source. Chemical modification of the nanoparticles' surface led to lung or liver targeting or to long-lasting blood circulation. Tumor mass could also be identified on a mouse model.Keywords
This publication has 48 references indexed in Scilit:
- Expression of recombinant Rhipicephalus (Boophilus) microplus, R. annulatus and R. decoloratus Bm86 orthologs as secreted proteins in Pichia pastorisBMC Biotechnology, 2008
- Global comparative analysis of ESTs from the southern cattle tick, Rhipicephalus (Boophilus) microplusBMC Genomics, 2007
- Near-Infrared Fluorescent Deoxyglucose Analogue for Tumor Optical Imaging in Cell Culture and Living MiceBioconjugate Chemistry, 2006
- Polymorphism of the bm86 Gene in South American Strains of the Cattle Tick Boophilus microplusExperimental and Applied Acarology, 2005
- BmiGI: A database of cDNAs expressed in Boophilus microplus, the tropical/southern cattle tickInsect Biochemistry and Molecular Biology, 2005
- Advances in In Vivo Bioluminescence Imaging of Gene ExpressionAnnual Review of Biomedical Engineering, 2002
- Immunization of cattle with synthetic peptides derived from the Boophilus microplus gut protein (Bm86)Veterinary Immunology and Immunopathology, 2002
- Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assaysJournal of Molecular Endocrinology, 2000
- Uptake of Liposomes Containing Phosphatidylserine by Liver Cellsin Vivoand by Sinusoidal Liver Cells in Primary Culture:In Vivo–in VitroDifferencesBiochemical and Biophysical Research Communications, 1999
- STRUCTURES AND FUNCTIONS OF MULTILIGAND LIPOPROTEIN RECEPTORS: Macrophage Scavenger Receptors and LDL Receptor-Related Protein (LRP)Annual Review of Biochemistry, 1994