Relationship of Endocrine State to Spontaneous Motility of Sheep Myometrium

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Abstract
Spontaneous motility of myometrial strips incubated in vitro was studied during the estrous cycle and following ovariectomy. The amplitude of contraction, frequency of contraction and an activity index (amplitude Xfrequency) were used to assess uterine motility. Among estrous, luteal phase and ovariectomized ewes, amplitude, frequency and activity index were each greatest in estrous ewes and lowest in luteal-phase ewes. Estradiol injected into ovariectomized ewes increased the frequency but not the amplitude of contraction, while progesterone injected into ovariectomized ewes decreased both frequency and amplitude of contraction. Acetylcholine or oxytocin caused sustained contraction of myometrium of ewes from all endocrine groups. Epinephrine had effects similar to acetylcholine or oxytocin in estrous and luteal phase ewes, but stopped activity in ovariectomized ewes.

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