DT-diaphorase protects cells from the hypoxic cytotoxicity of indoloquinone EO9
Open Access
- 1 December 1994
- journal article
- Published by Springer Nature in British Journal of Cancer
- Vol. 70 (6) , 1136-1143
- https://doi.org/10.1038/bjc.1994.461
Abstract
No abstract availableKeywords
This publication has 27 references indexed in Scilit:
- Chemosensitivity to the indoloquinone EO9 is correlated with DT-diaphorase activity and its gene expressionBiochemical Pharmacology, 1994
- Unusually marked hypoxic sensitization to indoloquinone E09 and mitomycin C in a human colon‐tumour cell line that lacks DT‐diaphorase activityInternational Journal of Cancer, 1994
- EO9: A novel bioreductive alkylating indoloquinone with preferential solid tumour activity and lack of bone marrow toxicity in preclinical modelsEuropean Journal Of Cancer, 1993
- Bioactivation of Mitomycin C by Xanthine Dehydrogenase From EMT6 Mouse Mammary Carcinoma TumorsJNCI Journal of the National Cancer Institute, 1992
- The sensitivity of human tumour cells to quinone bioreductive drugs: What role for DT-diaphorase?Biochemical Pharmacology, 1992
- DT-diaphorase and cancer chemotherapyBiochemical Pharmacology, 1992
- Enzymology of the reductive bioactivation of SR 4233Biochemical Pharmacology, 1990
- The differential hypoxic cytotoxicity of bioreductive agents determined in vitro by the MTT assayInternational Journal of Radiation Oncology*Biology*Physics, 1989
- Generation of hydroxyl radical by anticancer quinone drugs, carbazilquinone, mitomycin C, aclacinomycin A and adriamycin, in the presence of NADPH-cytochrome P-450 reductaseBiochemical Pharmacology, 1982
- One-electron-transfer reactions in biochemical systems V. Difference in the mechanism of quinone reduction by the NADH dehydrogenase and the NAD(P)H dehydrogenase (DT-diaphorase)Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1970