DNA sequence from the unzipping force? : one mutation problem

Preprint

17 July 2002

preprint
Published by arXiv in arXiv

https://doi.org/10.48550/arXiv.cond-mat/0106110

Abstract

The possibility of detecting mutations in a DNA from force measurements (as a first step towards sequence analysis) is discussed theoretically based on exact calculations. The force signal is associated with the domain wall separating the zipped from the unzipped regions. We propose a comparison method (``differential force microscope'') to detect mutations. Two lattice models are treated as specific examples.

Keywords

SEQUENCE ANALYSIS
MUTATION PROBLEM
DETECT MUTATIONS
UNZIPPING FORCE
DNA SEQUENCE
MUTATIONS
UNZIPPED
LATTICE

All Related Versions

Version 1, 2001-06-06, ArXiv
Version 2, 2002-07-17, ArXiv
Published version: Journal of Physics A: General Physics, 35 (26), L349.

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