Tissue Disposition of 2′‐O‐(2‐methoxy) ethyl Modified Antisense Oligonucleotides in Monkeys
- 1 January 2004
- journal article
- research article
- Published by Elsevier in Journal of Pharmaceutical Sciences
- Vol. 93 (1) , 48-59
- https://doi.org/10.1002/jps.10473
Abstract
No abstract availableKeywords
This publication has 22 references indexed in Scilit:
- A Nonradioisotope Biomedical Assay for Intact Oligonucleotide and Its Chain-Shortened Metabolites Used for Determination of Exposure and Elimination Half-Life of Antisense Drugs in TissueAnalytical Biochemistry, 1999
- Pharmacokinetics and Metabolism of an Oligodeoxynucleotide Phosphorothioate (GEM91®) in Cynomolgus Monkeys Following Intravenous InfusionAntisense and Nucleic Acid Drug Development, 1998
- Pharmacokinetic Properties of Phosphorothioate OligonucleotidesNucleosides and Nucleotides, 1997
- In VivoMetabolic Profile of a Phosphorothioate OligodeoxyribonucleotideAntisense and Nucleic Acid Drug Development, 1997
- A Nonradioisotope Approach to Study theIn VivoMetabolism of Phosphorothioate OligonucleotidesAntisense and Nucleic Acid Drug Development, 1997
- On-Line HPLC Electrospray Mass Spectrometry of Phosphorothioate Oligonucleotide MetabolitesAnalytical Chemistry, 1997
- Structural modifications toward improved antisense oligonucleotidesPerspectives in Drug Discovery and Design, 1996
- Quantitation of Phosphorothioate Oligonucleotides in Human PlasmaAnalytical Biochemistry, 1996
- Effect of different chemically modified oligodeoxynucleotides on immune stimulationBiochemical Pharmacology, 1996
- Pharmacokinetics of Antisense OligonucleotidesClinical Pharmacokinetics, 1995