Physical Stability of Proteins in Aqueous Solution: Mechanism and Driving Forces in Nonnative Protein Aggregation
Top Cited Papers
- 1 January 2003
- journal article
- review article
- Published by Springer Nature in Pharmaceutical Research
- Vol. 20 (9) , 1325-1336
- https://doi.org/10.1023/a:1025771421906
Abstract
Irreversible protein aggregation is problematic in the biotechnology industry, where aggregation is encountered throughout the lifetime of a therapeutic protein, including during refolding,...Keywords
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