Synthesis and Biological Evaluation of a Series of Substituted Pyridine-C-Nucleosides. Part V: 3-Chloro-4-(D-Ribofuranosyl)Pyridine and 3-(D-Ribofuranosyl)-2-Pyridone
- 1 January 1989
- journal article
- research article
- Published by Taylor & Francis in Nucleosides, Nucleotides and Nucleic Acids
- Vol. 8 (3) , 307-315
- https://doi.org/10.1080/07328318908054176
Abstract
The total synthesis of 3-chloro-4-(D-ribofuranosyl)-pyridine and 3-(D-ribo-furanosyl)-2-pyridone was elaborated using the appropriate lithiopyridines and 2,4:3,5-di-O-benzylidene-aldehydo-D-ribose. The conformation of these compounds was investigated by 360 MHz 1H-NMR. The compounds were evaluated as α,β-mixtures for their antiviral and cytostatic properties. However, no significant biological activity was found.This publication has 12 references indexed in Scilit:
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