IS THE DIABETOGENIC EFFECT OF STREPTOZOTOCIN IN PART THYMUS‐DEPENDENT?
- 1 November 1978
- journal article
- research article
- Published by Wiley in Acta Pathologica Microbiologica Scandinavica Section C Immunology
- Vol. 86C (1-6) , 23-27
- https://doi.org/10.1111/j.1699-0463.1978.tb02552.x
Abstract
Following a single injection of 200 mg streptozotocin/kg body weight, 25 of 25 normal mice became diabetic; 12 (20%) of 59 athymic nude mice did not develop diabetes. In a multiple dosage experiment, where the same total dose was given over a 5 day period, 14 normal and 15 athymic nude mice all became diabetic, but nude mice had significantly lower blood glucose values. A thymus dependent immune reaction may be, in part, responsible for the diabetogenic effect of streptozotocin.Keywords
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