EVALUATION OF THE "LONG CHAIN REACTION" AS A MEANS FOR DETECTING TYPE-SPECIFIC ANTIBODY TO GROUP A STREPTOCOCCI IN HUMAN SERA

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Abstract
Certain strains of Group A streptococci showed striking increase in chain length when grown in liquid media to which was added human sera that contained antibody to M protein of homologous type. This "long chain reaction" was shown to be a highly specific and sensitive biological test for human type-specific antibody and correlated closely with the classical bactericidal test.