MHPG as a predictor of antidepressant response to imipramine and maprotiline
- 1 September 1980
- journal article
- research article
- Published by American Psychiatric Association Publishing in American Journal of Psychiatry
- Vol. 137 (9) , 1090-1092
- https://doi.org/10.1176/ajp.137.9.1090
Abstract
To determine if depressed patients with low pretreatment levels of urinary 3-methoxy-4-hydroxyphenylglycol (MHPG) respond more favorably to antidepressant drugs which act on noradrenergic neuronal systems than do patients with high MHPG levels, 150-200 mg/day of imipramine or maprotiline was given to 13 depressed patients. All of the 5 patients with low pretreatment MHPG levels responded to treatment compared with 1 of the 14 patients with high MHPG levels; 4 patients dropped out of the study.This publication has 4 references indexed in Scilit:
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