THE INFLUENCE OF ALTERATIONS IN ACID-BASE BALANCE UPON TRANSFERS OF CARBON DIOXIDE AND BICARBONATE IN MAN 1

Open Access
Publisher Website
Google Scholar
Abstract
The influence of changes in acid-base equilibrium upon the output of CO2 by the lungs was studied in human subjects. Overventilation produced large increments in respiratory output of CO2. A portion of the CO2 was given up by the tissues. Ventilation with a CO2- enriched air caused a marked diminution in the CO2 vol. given out by the lungs. Part of the CO2 retention was intracellular. Alterations of the CO2 content of blood, produced by ingestion of NH4Cl, may be unassociated with any significant change in the output of CO2 by the lungs. The vol. of distribution of bicarbonate ion administered intraven. as Na bicarbonate approximated the extracellular fluid vol. as detd. by the thiocyanate method. The observations indicate that the tissue cells of man are freely permeable to dissolved molecular CO2, but are impermeable to bicarbonate ion.

This publication has 17 references indexed in Scilit: