Red Blood Cell Transketolase Activity and the Effect of Thiamine Supplementation in Patients with Chronic Liver Disease
- 23 February 1978
- journal article
- research article
- Published by Taylor & Francis in Scandinavian Journal of Gastroenterology
- Vol. 13 (2) , 133-138
- https://doi.org/10.3109/00365527809181738
Abstract
Biochemical evidence of thiamine deficiency was found in 58% of patients with chronic liver disease, the incidence being higher in alcoholic than in non-alcoholic patients. Daily supplementation with high doses of thiamine hydrochloride (200 mg/day) for 1 wk restored levels of thiamine pyrophosphate (TPP), the active co-enzyme form of thiamine, to normal in all cases. Such supplementation also stimulated synthesis of the TPP-dependent enzyme transketolase. Because of the essential role of TPP as a co-factor in intermediary metabolism, high doses of thiamine should be included in the routine nutritional management of patients with severe chronic liver disease.This publication has 13 references indexed in Scilit:
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