Comparative bactericidal effect of ceforanide (BL-S 786) and five other cephalosporins in an in vitro pharmacokinetic model.

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Abstract
The bactericidal activity of ceforanide was compared, in an in vitro kinetic model, with that of 5 other cephalosporins: cephalothin, cefazolin, cefamandole, cefuroxime and cefoxitin. Cultures of various pathogens in 95% human serum were incubated for 12 h in the presence of the cephalosporins whose concentrations were modified periodically, by addition of a concentrated solution of drug or dilution with unmedicated serum to simulate the variation of antibiotic concentration in human blood after a g i.m. dose. One gram-positive strain and 6 gram-negative strains were used. Bactericidal activity was assessed by monitoring changes in the number of colony-forming units. Tests showed that against Klebsiella pneumoniae, ceforanide was the most active of the 6 cephalosporins. Proteus mirabilis was more susceptible to ceforanide and cefuroxime than to the other compounds; Enterobacter cloacae to ceforanide, cefuroxime and cefamandole; Escherichia coli to cerforanide, cefuroxime, cefamandole and cefazolin. The number of viable cells of Staphylococcus aureus was reduced below detectable levels by all cephalosporins except cefoxitin. P. inconstans was virtually unaffected by all of the cephalosporins except cefoxitin.