HEMOGLOBIN INHERITANCE IN INBRED MOUSE STRAINS, II. GENETIC STUDIES

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Abstract
Genetic studies using a tryptophan-contaihing peptide as marker for the beta chain of C57BL hemoglobin showed that this chain was linked to the albino locus and that the 2 [beta]-chains of AKR (or FL) remained together and segregated as a unit from the C57BL [beta]-chain. Using a histidine-containing peptide as marker for the [alpha]-chain of FL hemoglobin, it was found that the [alpha]- and [beta]-chains segregate independently. It was demonstrated that this aberrant a-chain is not associated with the fetal anemia found in mice of the FL inbred stain.