DER EINFLUSS VON THYREOTROPIN, ADRENALIN UND ADENOSINTRIPHOSPHORSÄURE AUF DIE REGULATION DES JODHAUSHALTES

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Abstract
The influence of thyrotropic hormone, epinephrine, and adenosine triphosphate on the iodine fractions in the blood of 38 persons was investigated. Treatment of 3 normal subjects treated with 500-1500 guinea pig Units of thyrotropin (TSH) for 1-3 days was followed by a marked absolute or relative increase in the thyroxin content of plasma albumin. After epinephrine injns., 6 normal and 18 obese persons initially exhibited decreased levels of protein bound I and increased levels of inorganic I. These plasma changes released thyrotropic hormone and blood I changes now simulated those following injn. of TSH. The intraven. admn. of 20-30 mg. adenosine triphosphate in 2 patients with hyperthyroidism was followed by a distinct drop in basal metabolic rate. However, this decrease of O2-consumption was accompanied by no change of the organic but slight increase of the inorganic blood I. It is concluded that the I metabolism may be influenced by a central and a peripheral mechanism, which are dependent on a normal function of the anterior lobe of the hypophysis.