THE METABOLIC SIGNIFICANCE OF PROTEINBOUND IODINE OF PLASMA: A STUDY OF ITS CONCENTRATION UNDER VARIOUS CONDITIONS AND OF ITS RATE OF FORMATION AS MEASURED WITH RADIOACTIVE IODINE1
- 1 January 1947
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 40 (1) , 47-54
- https://doi.org/10.1210/endo-40-1-47
Abstract
The plasma protein-bound iodine of adult d" rats showed a significant decrease within 4 hrs. following thyroidectomy, and a 30% decrease after 12 hrs. Three and 16 days after thyroidectomy, the protein-bound I was 1.1 and 1.0 y %, respectively (normal 3.2). Fifty % of radioactive I (I131) after introduction into normal rats is found as protein-bound I within 13 hrs., 90% in 24 hrs., while only 5-10% is found as protein-bound I in thy-roidectomized animals. Guinea pigs and rats injected with thyrotrophic hormone showed an increased speed of appearance of protein-bound I following admn. of I131, the rate of conversion being a guide of thyroid activity.Keywords
This publication has 7 references indexed in Scilit:
- ON THE DETERMINATION OF PLASMA IODINEJournal of Biological Chemistry, 1946
- THE DETERMINATION OF THYROXINE IN THE THYROID GLAND OF THE RATJournal of Biological Chemistry, 1946
- THE INFLUENCE OF HYPOPHYSECTOMY UPON PLASMA IODINE AND THYROXINE CONTENT OF THE THYROID GLAND OF THE RAT1Endocrinology, 1946
- The Protein-Bound Plasma Iodine in Patients with Thyroid DiseaseJournal of Clinical Endocrinology & Metabolism, 1944
- SERUM IODINE FRACTIONS IN HYPERTHYROIDISM 12Journal of Clinical Investigation, 1942
- PROTEIN-BOUND IODINE IN BLOOD.The Lancet Healthy Longevity, 1941
- THE FRACTIONATION OF THE IODINE OF THE BLOOD IN THYROID DISEASEJournal of Clinical Investigation, 1939