Human lymphocyte Fc receptor for IgE: sequence homology of its cloned cDNA with animal lectins.
- 1 February 1987
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 84 (3) , 819-823
- https://doi.org/10.1073/pnas.84.3.819
Abstract
We have purified the human lymphocyte Fc receptor specific for IgE (Fc.epsilon. receptor) and its soluble form by using the anti-Fc.epsilon. receptor monoclonal antibody H107. Using an oligonucleotide probe corresponding to the partial amino acid sequence of the soluble Fc.epsilon. receptor related to IgE binding factor, we cloned, sequenced, and expressed a cDNA for the receptor. The Fc.epsilon. receptor has 321 amino acid residues with no NH2-terminal signal sequence. The receptor was separated into two domains by a putative 24-amino acid residue transmembrane region located near the NH2-terminal end. The Fc.epsilon. receptor showed a marked homology with animal lectins including human and rat asialoglycoprotein receptors, chicken hepatic lectin, and rat mannose binding proteins.This publication has 31 references indexed in Scilit:
- Dideoxy sequencing method using denatured plasmid templatesAnalytical Biochemistry, 1986
- Lack of Fc receptor for IgE in SJA9 miceImmunogenetics, 1985
- T and B lymphocytes with immunoglobulin E Fc receptors (FcϵR) in patients with nonallergic hyperimmunoglobulinemia E: Demonstration using a monoclonal antibody against FcϵR-associated antigenClinical Immunology and Immunopathology, 1985
- cDNA clones encoding IgE-binding factors from a rat-mouse T-cell hybridoma.Proceedings of the National Academy of Sciences, 1985
- Molecular cloning of cDNA encoding human interleukin-2 receptorNature, 1984
- NH2-terminal hydrophobic region of influenza virus neuraminidase provides the signal function in translocation.Proceedings of the National Academy of Sciences, 1984
- Immobilization of enzymes and affinity ligands to various hydroxyl group carrying supports using highly reactive sulfonyl chloridesBiochemical and Biophysical Research Communications, 1981
- Plasmid screening at high colony densityGene, 1980
- Cloning and complete nucleotide sequence of mouse immunoglobulin γ1 chain geneCell, 1979
- Lymphocytes with Immunoglobulin E Fc Receptors in Patients with Atopic DisordersJournal of Clinical Investigation, 1979