Reductive Amination with Zinc Borohydride. Efficient, Safe Route to Fluorinated Benzylamines
- 1 December 1997
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 27 (24) , 4265-4274
- https://doi.org/10.1080/00397919708005050
Abstract
Fluorinated benzylamines are synthesized in high yields by reductive alkylation of secondary amines with appropriate fluoroaldehydes using a combination of zinc chloride and zinc borohydride. The present method offers an alternative to toxic sodium cyanoborohydride and is adaptable to multigram-scale preparations.Keywords
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