Susceptibility of Enterococci and of Hemolytic Streptococci of Groups A, B, C, and G to Five New AntibioticsIn Vitro

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Abstract
In vitro, erythromycin was the most active, and cycloserine the least active; novobiocin was appreciably less active than the other 3 antibiotics studied, namely, oleandomycin, spiramycin, and streptogramin, each of which has exhibited some cross-resistance with erythromycin. Of the 3 erythromycin-like agents, spiramycin was the most active against enterococci, streptogramin against the strains of other groups, and oleandomycin had an intermediate activity against all of the groups tested. Strains of groups A, B, C, and G ranked in that order in their susceptibility to streptogramin and cycloserine; otherwise, there did not seem to be any relation between the specific groups of hemolytic streptococci or the species of enterococci (group D streptococci), and the susceptibility to each of the antibiotics included in this study.