IDENTIFICATION OF 2-IMIDAZOLINES AS ANTI-SICKLING AGENTS

  • 1 January 1983
    • journal article
    • research article
    • Vol. 23  (3) , 731-734
Abstract
The drugs tolazoline, clonidine, lofexidine and fenmetozole inhibited the gelation human S in the order of increasing effectiveness. Only the latter reduced the sickling or red cells significantly and normalized the oxygen affinity of SS blood at 5-10 mM concentrations. Since this level of drug is lower than those reported for many other anti-sickling agents to achieve comparable effects, the 2-imidazoline class of compounds may provide important clues for the development of therapy for sickle cell anemia.