Topical Tioconazole in Deimatomycosis: Lokalbehandlung mit Tioconazol bei Dermatomykosen

Publisher Website
Google Scholar
Abstract
Zusammenfassung: Eine doppelblinde Vergleichstudie über die antimykotische Wukung und Verträglichkeit einer 2 %igen Tioconazol‐Salbe und des entsprechenden Vehikels wurde bei der Therapie von Dermatomykosen durchgeführt. Tioconazolsalbe zeigte sich sowohl klinisch (p Summary: A double‐blind comparison of the efficacy and safety of 2 % tioconazole hydrochloride and vehicle creams was carried out in the treatment of fungal infections of the skin. Tioconazole cream proved significantly more effective than the vehicle, both clinically (p<0.001) and mycologically (p<0.001); 14 out of the 17 patients treated with tioconazole cream for four weeks were cured mycologically (82.4%).Seventeen of the vehicle treated patients were later taken into an open study where they were treated with tioconazole cream. Sixteen were cured mycologically (94.1%) and one patient was clinically cured but mycologically still infected.At a follow‐up 6 weeks after the completion of treatment, 34 patients were reviewed, and 27 (79 %) were clinically and mycologically free of infection. Trichophyton rubrum was cultured in 3 patients; 4 patients were mycologically cured but showed still some clinical signs.One patient with previous contact sensitivities developed an allergic reaction to tioconazole. Otherwise the creams were well tolerated and there was no staining of skin or clothing. There were no drug related abnormalities in the laboratory tests.

This publication has 4 references indexed in Scilit: