EVALUATION OF MONOVALENT INFLUENZA VACCINES

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Abstract
1. During an epidemic of influenza A, caused by an A-prime strain, the incidence of patients hospitalized with influenza was 1.2 per cent among personnel who had received a monovalent FM1 vaccine. In two comparable control groups the incidence figures were 4.0 per cent and 4.2 per cent. 2. The degree of protection obtained with the A-prime vaccine was comparable to that observed in earlier influenza A epidemics with vaccines prepared from the PR8 and Weiss strains. 3. A monovalent PR8 vaccine failed to provide a significant degree of protection. 4. The incidence of respiratory diseases other than influenza did not show significant differences in the groups which had received the 4 vaccines. 5. There appeared to be a good correlation between low antibody titer, as measured by agglutination-inhibition tests with closely related strains, and the probability of clinical infection.