Urinary metabolites of N-nitrosodipropylamine, N-nitroso-2-hydroxypropylpropylamine and N-nitroso-2-oxo-propylpropylamine in the rat

Publisher Website
Google Scholar
Abstract
Analysis of 24 h urine samples of rats administered N-nitrosodipropylamine (NDPA), N-nitroso-2-hydro-xypropylpropylamine (NHPPA) or N-nitroso-2-oxo-propylpropylamine (NOPPA) showed that the major excretion product in each case was the β-glucuronide of NHPPA. This conjugate was shown to be present at levels of about 5%, 80% and 50% of the administered dose for NDPA, NHPPA and NOPPA, respectively, based on exhaustive hydrolysis of the urine samples with β-glucuronidase. Generally only low levels (<2%) of the unchanged nitrosamines or their unconjugated metabolites (NHPPA for administered NDPA and NHPPA for administered NOPPA) were detected. We were unable to detect N-nitrosomethylpropylamine or N-nitrosodimethylamine in the urine of any of the animals.