Direct alkyl chain cleavage after C-hydroxylation of dialkylinitrosamines in rats. A new pathway of the oxidative biotransformation

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Abstract
Comparative in vivo investigations on the biotransformation of di-n-butylnitrosamine (DBNA) and (2-hydroxybutyl)-n-butylnitrosamine (HBBNA) showed the known ω-oxidation. However, a new metabolic mechanism of direct oxidative alkyl chain cleavage in the vicinity of the hydroxy group of HBBNA could be demonstrated. Vergleichende Untersuchungen über die Biotransformation von di-n-butylnitrosamin (DBNA) und (2-hydroxybutyl)-n-butylnitrosamin (HBBNA) in vivo zeigten, daß außer der bekannten ω-Oxidation auch direkte oxidative Alkylkettenspaltung neben der OH-Gruppe von HBBNA stattfindet.

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