ROUTINE SYNTHESIS OF L-[F-18]6-FLUORODOPA WITH F-18 ACETYL HYPOFLUORITE
- 1 September 1986
- journal article
- research article
- Vol. 27 (9) , 1462-1466
Abstract
The synthesis of L-[18F]6-fluorodopa (2,4-10.6 mCi) was done by passing gaseous [18F]acetyl hypofluorite through a solution of L-methyl-N-acetyl-[.beta.-(3-methoxy-4-acetoxyphenyl)]alaninate in acetic acid at room temperature followed by the hydrolysis of the intermediate products with concentrated hydirodic acid. The desired fluorodopa isomer was isolated in 8% EOB radiochemical yield by high performance liquid chromatography in an overall synthesis time of 100 min.This publication has 4 references indexed in Scilit:
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- AROMATIC RADIOFLUORINATION WITH [F-18] FLUORINE-GAS - 6-[F-18] FLUORO-L-DOPA1984