Transient Neonatal Cryptosporidium parvum Infection Triggers Long-Term Jejunal Hypersensitivity to Distension in Immunocompetent Rats

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Abstract
In 5-day-old immunocompetent Sprague-Dawley rats infected with either 10 2 or 10 5 Cryptosporidium parvum oocysts, transient infection resulted 120 days later in increased cardiovascular depressor response to jejunal distension and jejunal myeloperoxidase activity ( P < 0.05). Nitazoxanide treatment normalized jejunal sensitivity ( P < 0.001) but not myeloperoxidase levels ( P > 0.05). Data warrant further evaluation of the role of early cryptosporidiosis in the development of chronic inflammatory gut conditions.