Oxidative Rates and Phosphorylation in Sarcosomes from Experimentally-Induced Failing Rat Heart.
- 1 November 1964
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 117 (2) , 380-383
- https://doi.org/10.3181/00379727-117-29586
Abstract
Summary Abdominal aortic constriction was used to induce cardiac hypertrophy in the rat. Sarcosomes isolated from these hearts had significantly lower respiratory rates. The % decrease in Qo2 was 34%, 26%, 32% and 25% with α-ketoglutarate, pyruvate, succinate and malate respectively. With these substrates in the same order the efficiency of phosphorylation was also significantly decreased by 15%, 12%, 26% and 12%.Keywords
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