SYNTHESIS, DNA-BINDING AND ANTIVIRAL ACTIVITY OF DISTAMYCIN ANALOGS CONTAINING DIFFERENT HETEROCYCLIC MOIETIES

  • 1 November 1986
    • journal article
    • research article
    • Vol. 1  (3) , 235-244
Abstract
A series of novel distamycin analogues possessing an additional benzene or heterocyclic ring have been synthesised and tested for selective DNA binding properties and antiviral activity. Inhibition of herpes virus in cell culture appears to be related to A.cntdot.T base pair specificity. Some of the new compounds are also more potent than the parent distamycin against Moloney sarcoma virus.