CROSS-REACTIVE ANTIBODIES AGAINST HUMAN CULTURED B CELLS AND BOVINE ERYTHROCYTES IN HUMAN RENAL TRANSPLANTATION SERA

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Abstract
Sera of 58 recipients of renal allografts were studied for the presence of antibodies against cell cultures of human B [bone marrow-derived] lymphoid cell lines (B-LCL) and bovine erythrocytes (BRBC). Cytotoxic anti-B-LCL antibodies were found in 13% of the sera from recipients with the grafts and in 67% of the sera obtained after removal of the rejected grafts. Most of these sera also contained BRBC lysins of high titers. Absorption studies showed that the anti-B-LCL antibodies were directed against antigens shared by BRBC and that they can be absorbed with corresponding graft tissues. The specificity of BRBC lysins found in some of the transplantation sera was similar to that of Hanganutziu-Deicher antibodies.