Multiple red cell antigen loss in acute granulocytic leukemia

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Abstract
Loss of certain red blood cell antigens has been described in various disease states including acute granulocytic leukemia (AGL). This paper describes the loss of blood group A antigen in three patients, two with AGL and a third with a myeloproliferative disorder similar to AGL which developed following total body irradiation for malignant, well-differentiated lymphocytic lymphoma. In the latter case, the onset of the myeloproliferative disease correlated with the loss of A antigen. In addition to A antigen loss, all three patients' red cells showed the loss of Lewisb antigen, a finding previously unreported. Finally, the two patients with AGL also exhibited the loss of I antigen from their red cells. Cancer 42:2248–2253, 1978.