Asymmetric Synthesis of Quaternary α- and β-Amino Acids and β-Lactams via Proline-Catalyzed Mannich Reactions with Branched Aldehyde Donors
- 25 June 2004
- journal article
- research article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 6 (15) , 2507-2510
- https://doi.org/10.1021/ol049248+
Abstract
L-Proline-catalyzed direct asymmetric Mannich reactions of N-PMP protected α-imino ethyl glyoxylate with various α,α-disubstituted aldehydes affords quaternary β-formyl α-amino acid derivatives with excellent yields and enantioselectivities. The Mannich products are further converted to the corresponding quaternary α- and β-amino acids and β-lactams.Keywords
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