BIOLOGICAL ENERGY TRANSFORMATIONS DURING SHOCK AS SHOWN BY TISSUE ANALYSES

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Abstract
A study has been made of tissue from rats in shock produced by tumbling in the Noble-Collip drum, by production of ischemia in leg muscles and by poisoning with nembutal. Analyses were made of brain, skeletal muscle, liver, kidney and heart for some 16 components, including the rapidly mobilizable energy reservoirs and products of glycolysis. The tissues of animals in shock exhibit greatly elevated inorganic phosphate and lactic acid, depleted glycogen, ATP and phos-phocreatine, and possess an abnormal accumulation of phos-phopyruvic acid. They appear to expire because of exhaustion in the respiratory and vasomotor centers, though this is evidently preceded in certain cases by liver failure and probably failure of the mechanisms for mobilization of carbo-hydrate from body protein, which conversion is necessary because the tissues must operate largely with the anaerobic glycolytic mechanisms. Animals demonstrated to be resistant, when subjected to the same trauma, did not show the above-mentioned changes, and rapidly adjusted to normal after the trauma.