Effect of Goldthioglucose Injections on Survival, Organ Damage and Obesity in the Rat.
- 1 January 1963
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 112 (1) , 33-37
- https://doi.org/10.3181/00379727-112-27942
Abstract
Preliminary studies showed that weanling Long-Evans rats are less susceptible to goldthioglucose than are adults; the LD50 for 50 g animals was 0.25 mg/g. Some adult Sprague-Dawley rats were found to withstand doses of GTG that were lethal to adult Long-Evans rats, and to demonstrate a developing obesity. More severe VMH lesions were seen in female than in male rats following GTG injection. Glial damage without neuronal destruction appeared in several GTG-injected rats. Treatment with phlorhizin and BAL reduced renal damage produced by GTG injection. GTG injection, in adult rats, produced a triphasic blood-glucose pattern.Keywords
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