Stopping rules for clinical trials
- 1 April 1983
- journal article
- research article
- Published by Wiley in Statistics in Medicine
- Vol. 2 (2) , 167-174
- https://doi.org/10.1002/sim.4780020210
Abstract
We describe a new method of formulating stopping rules for clinical trials, one that incorporates opinion on what difference is clinically important. We compare the method with conventional group sequential designs and illustrate it by application to a study of Pancuronium Bromide for prevention of haemorrhage in pre‐term infants.Keywords
This publication has 5 references indexed in Scilit:
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- The Importance of Beta, the Type II Error and Sample Size in the Design and Interpretation of the Randomized Control TrialNew England Journal of Medicine, 1978
- Group sequential methods in the design and analysis of clinical trialsBiometrika, 1977
- Statistics and Medical ExperimentationBiometrics, 1975