Morphogen to mitogen: the multiple roles of hedgehog signalling in vertebrate neural development
Top Cited Papers
- 1 October 2006
- journal article
- review article
- Published by Springer Nature in Nature Reviews Neuroscience
- Vol. 7 (10) , 772-783
- https://doi.org/10.1038/nrn1990
Abstract
Sonic hedgehog has received an enormous amount of attention since its role as a morphogen that directs ventral patterning in the spinal cord was discovered a decade ago. Since that time, a bewildering array of information has been generated concerning both the components of the hedgehog signalling pathway and the remarkable number of contexts in which it functions. Nowhere is this more evident than in the nervous system, where hedgehog signalling has been implicated in events as disparate as axonal guidance and stem cell maintenance. Here we review our present knowledge of the hedgehog signalling pathway and speculate about areas in which further insights into this versatile pathway might be forthcoming.Keywords
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