IMMUNOHISTOCHEMICAL STUDY OF THE RAS ONCOGENE EXPRESSION IN HUMAN-BREAST LESIONS
- 1 September 1986
- journal article
- research article
- Vol. 6 (5) , 1157-1160
Abstract
An immunohistochemical study of ras oncogene expression in human breast lesions was carried out using a monoclonal antibody. Y13 259, to the ras encoded p21 protein. A total of 75 cases of breast disease examined included: 33 simple and complex cystic disease; 22 simple and hyperplastic fibroadenomas; 18 ductal, lobular and mixed carcinomas and 2 in situ carcinomas. Most of the complex cystic disease, hyperplastic fibroadenomas and all types of carcinomas showed high p21 expression as indicated by staining intensity. These results suggest that elevated ras expression may play an important role in the development of some premalignant and malignant breast lesions.This publication has 21 references indexed in Scilit:
- Monoclonal antibodies of predefined specificity detect activated ras gene expression in human mammary and colon carcinomas.Proceedings of the National Academy of Sciences, 1984
- Comparative biochemical properties of normal and activated human ras p21 proteinNature, 1984
- Malignant transformation of early passage rodent cells by a single mutated human oncogeneNature, 1984
- Elevated expression of the human ras oncogene family in premalignant and malignant tumours of the colorectumBritish Journal of Cancer, 1984
- Autophosphorylation of v-Ha-ras p21 is modulated by amino acid residue 12.Proceedings of the National Academy of Sciences, 1984
- HUMAN-MALIGNANT TUMORS OF THE BREAST, AS COMPARED TO THEIR RESPECTIVE NORMAL TISSUE, HAVE ELEVATED EXPRESSION OF THE HARVEY RAS ONCOGENE1984
- Monoclonal antibodies to the p21 products of the transforming gene of Harvey murine sarcoma virus and of the cellular ras gene familyJournal of Virology, 1982
- Tumorigenic transformation of mammalian cells induced by a normal human gene homologous to the oncogene of Harvey murine sarcoma virusNature, 1982
- Guanine nucleotide-binding and autophosphorylating activities associated with the p21src protein of Harvey murine sarcoma virusNature, 1980
- Localization of the src gene product of the Harvey strain of MSV to plasma membrane of transformed cells by electron microscopic immunocytochemistryCell, 1980