Isolations of a Cartilage Factor That Inhibits Tumor Neovascularization
- 2 July 1976
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 193 (4247) , 70-72
- https://doi.org/10.1126/science.935859
Abstract
A cartilage fraction isolated by guanidine extraction and purified by affinity chromatography inhibits tumor-induced vascular proliferation and consequently restricts tumor growth. This fraction contains several different proteins; the major one has a molecular weight of about 16,000. The fraction strongly inhibits protease activity.Keywords
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