Determination and Confirmation of Chloramphenicol Residues in Swine Muscle and Liver
- 1 January 2002
- journal article
- Published by Wiley in Journal of Food Science
- Vol. 67 (1) , 21-28
- https://doi.org/10.1111/j.1365-2621.2002.tb11352.x
Abstract
Average high‐performance liquid chromatography (HPLC) recoveries of chloramphenicol (CAP) in swine muscle and liver ranged from 91.3 to 94.2% and 93.1 to 103.7%, respectively, with coefficients of variation ranging from 1.4 to 4.3% and 1.1 to 11.2% for each tissue sample. The method described was repeatable and reproducible in swine muscle and liver, with a limit of quantification of 15 ng/mL and a limit of detection estimated at 5 ng/mL. The limit of identification of CAP was 25 ng/mL, 5ng/mL, and 20 ng/mL for HPLC/PDA, GC/MS selected ion monitoring (SIM), and LC/MS analysis, respectively.Keywords
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