The Effect of Cimetidine on Gastrin Release in Ulcer Disease

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Abstract
The effect of a single dose of 400 mg of the H2-receptor antagonist cimetidine on protein meal stimulated immunoreactive gastrin was assessed in 10 patients with gastric ulcer and 10 patients with duodenal ulcer. In gastric ulcer patients, serum gastrin (mean .+-. SE) rose from 34 .+-. 2.2 pmol.cntdot.l-1 to a peak of 80 .+-. 5.0 pmol.cntdot.l-1 at 45 min without and from 36 .+-. 2.2 to 107 .+-. 8.0 pmol.cntdot.l-1 at 60 min with cimetidine; in duodenal ulcer it rose from 26 .+-. 3.0 to 47 .+-. 5.1 pmol.cntdot.l-1 at 45 min without and 26 .+-. 3.2 to 52 .+-. 5.1 pmol.cntdot.l-1 at 60 min with cimetidine. Integrated gastrin responses in gastric ulcer were 4900 .+-. 800 pmol.cntdot.l-1 120 min without and 7000 .+-. 900 pmol.cntdot.l-1 120 min with cimetidine and 1560 .+-. 300 pmol.cntdot.l-1 120 min without and 2620 .+-. 400 pmol.cntdot.l-1 120 min with cimetidine in duodenal ulcer patients. These gastrin increases after cimetidine are comparable to those achieved with continuous intragastric neutralization with alkali.