Adaptive response of the yeastSaccharomyces cerevisiaeto reactive oxygen species: defences, damage and death

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Abstract
The yeast Saccharomyces cerevisiae has been extensively utilised to address the mechanisms underlying the oxidative stress response. The antioxidant defences can be induced either by respiratory growth or in the presence of pro-oxidants. The cell response involves the transcriptional control of genes by protein regulators that have been recently identified and post-translational activation of pre-existing defences. The current state of the art regarding the induction of antioxidant defences during respiratory growth and by exposure to hydrogen peroxide is reviewed.