Genetic control of cytolytic T lymphocyte responses. III. The role of K and I region alleles on the specificity of the cytolytic T lymphocyte response to trinitrophenyl-modified syngeneic cells.

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Abstract
It has previously been demonstrated that genes in the H-2K and/or I-A region control the specificity of the cytolytic T lymphocyte (CTL) response to trinitrophenyl-(TNP) modified syngeneic cells. Strains of mice bearing the k allele in the K and/or IA region do not exhibit cross-reactive lysis of TNP-modified allogeneic targets after stimulation with TNP-modified syngeneic targets. In this report we present evidence for independent roles of genes in the H-2K and I-A regions on the control of CTL specificity. One gene, mapping in the H-2K region, is expressed on the stimulator cell population, whereas the other gene maps to the I region and is expressed in the population of responding cells and need not be expressed in the stimulator cell population. Thus, we suggest that Ir genes localized to the I region may influence the response for prekiller cells to H-2K/D gene products.